Tottenham travel to Italian giants Juventus on Tuesday night and midfield enforcer Victor Wanyama should be recalled to the side.
The 26-year-old has been eased back into the action by manager Mauricio Pochettino from a long-term injury and has had to make do with mainly substitute appearances in the Premier League recently.
However, he would be the ideal candidate to start in midweek during the Champions League last 16 clash away to Juventus.
The north London club travel to Turin for the first leg of their meeting with the European heavyweights, who have kept 15 clean sheets in their last 16 games across all competitions.
Spurs are going to need a big physical presence to help gain a positive result and pairing Wanyama alongside Mousa Dembele would be a smart approach to take.
Wanyama is a powerhouse that could help nullify the Juventus threat going forward and is a key defensive player when he is on form.
His inclusion should mean that Pochettino mainstay Eric Dier drops out, but he is a big favourite of the manager and has already made 35 appearances to date this season.
The England international has been used as a midfielder recently, but his versatility also sees him often used as a third centre-back.
Dier, 24, should drop out of the midfield at the expense of Wanyama to give them a much more solid basis to defend with against Juventus in a huge European encounter.
Spurs should be targeting real success in the Champions League season after coasting through their difficult group and have the attacking firepower to dump out the experienced if they defend well.