Kieran Trippier, Cameron Carter-Vickers, Kevin Wimmer, Ben Davies
Expect a much-changed Tottenham back line with Spurs facing two away days at Middlesbrough and CSKA Moscow in the near future.
At right back, Kieran Trippier is the perfect like-for-like replacement for Kyle Walker who has been outstanding this season.
At centre back, Kevin Wimmer showed what a solid stand-in defender he is last term and the Austrian international would be receiving his first appearance of the season tonight.
Alongside him, Pochettino could plump for either first choice defenders Toby Alderweireld or Jan Vertonghen but we think he may hand a competitive debut to United States youth international Cameron Carter-Vickers.
Having appeared as an unused substitute on Spurs’ bench so far this season, the English-born Carter-Vickers is highly thought of at White Hart Lane and this seems the perfect opportunity.
At left back, surprise Chelsea transfer target Ben Davies adds experience to this much-changed back four.